Pan-cancer morphological atlas based on 6,745 TCGA tissue slides
HistoAtlas is a free and open web atlas that maps the morphology of cancerous tissues to molecular programs and patient survival, covering 21 cancer types. It analyzes 6,745 H&E-stained diagnostic slides from TCGA, extracts 38 quantitative histomic features (tumor morphology, immune infiltration, spatial organization, cell densities), and calculates over 10,000 statistical associations linking tissue architecture to genes, metabolic pathways, mutations, immune subtypes, and clinical outcomes. 100% free. No login required.
For cancer researchers, HistoAtlas enables the discovery of new histomic biomarkers associated with patient survival and molecular subtypes. For example, a researcher can identify specific spatial organization features that correlate with improved outcomes in a particular cancer type, guiding further experimental validation.
For pathologists, HistoAtlas provides a quantitative framework to explore tumor microenvironment heterogeneity across multiple cancer types. A pathologist can use the tool to investigate how variations in immune cell geography or stromal features correlate with different molecular profiles within a cohort, aiding in more precise diagnoses.
For bioinformatics students, HistoAtlas offers a practical platform to learn about integrating histopathological features with multi-omics data and clinical outcomes. A student can use the interactive UMAP embeddings to visualize how morphological clusters relate to gene expression patterns and survival data in TCGA datasets.
For oncology drug developers, HistoAtlas facilitates the identification of morphological features that are associated with specific molecular pathways or mutations relevant to drug targets. A developer can explore if certain tissue architectures are enriched in tumors with specific mutations, potentially informing patient stratification for clinical trials.
Yes, HistoAtlas is 100% free and open. No login is required to access its features and data.
HistoAtlas is a free resource and does not have any associated costs for users.
HistoAtlas is a pan-cancer morphology atlas that maps tissue morphology to molecular programs and patient survival. It analyzes histomic features from TCGA slides to link tissue architecture with genes, pathways, mutations, immune subtypes, and clinical outcomes.
HistoAtlas is a web-based atlas, meaning it can be accessed through any web browser on devices with internet connectivity, including mobile phones and tablets.
HistoAtlas analyzes 6,745 H&E-stained diagnostic slides from The Cancer Genome Atlas (TCGA). It extracts 38 quantitative histomic features related to tumor morphology, immune infiltration, spatial organization, and cell densities.
HistoAtlas provides interactive UMAP embeddings, survival analysis, and molecular correlations. It allows users to browse TCGA and CPTAC cancer cohorts and explore over 10,000 statistical associations between tissue architecture and various biological and clinical data.
We're still verifying the official pricing for HistoAtlas. In the meantime, the most up-to-date plans and prices are available directly on the publisher's website.
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